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Dr Mike Yeadon's avatar

Denis,

Excellent.

One point about antibiotics. I can’t speak for all of the not very many structural types, but some of them are intrinsically anti-inflammatory, independent of their ability to prevent bacterial replication in Petri dishes. It occurred to me when I was in Pfizer that their leading antibiotic might work in its leading indication, acute exacerbations of chronic obstructive pulmonary disease, by being anti inflammatory.

In practise, more or less impossible for distinguish.

I mention it, because I detected that you were convinced that, because agents termed antibiotics were useful in lung disease, this was pretty much proof of a pathogenic role for bacteria.

I’m only very slightly waggling that stake, because I pretty much agree with you (my remarks notwithstanding).

I think sequencing is going to turn out to be total fraud and nonsense. I already know enough to disregard the argument that “so many independent scientists found the same sequences, so there must be a contagious virus”.

First, I challenge the diversity of the sources. If they use the same machine’s & algorithms, that’s not diversity. And I think they do, or at least the methods & results are not truly independent. They also draw upon common databases and assumptions.

Next, the method used to determine (or is it form?) the “full length sequence” is not scientific. There’s extensive generation of short sequences, assumed to be contiguous, which are then assembled in the most plausible order using clever software. I understand the software makes no progress whatsoever until it’s presented with a potential skeleton, whereupon it assembles the contigs in a way that mimics it, with small variations. I don’t know enough to really understand the shell game that I suspect must be going on here. I have faith that you can get to the bottom of it, if you’ve time and inclination.

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Bernard Massie's avatar

I agree Denis, germ theory needs some serious reappraisal, but there are some foundations.

I’m a microbiologist by training and I have done research on antibiotic resistance for my PhD thesis. I have grown and studied the effect of bacteriophages and examined them using a number of methods, including electron microscopy. I then did a 3 years postdoc working on DNA tumor viruses, focusing on mouse polyomavirus. I have constructed the first adenoviral vector expressing polyoma tumor antigens to study their biology. I have subsequently generated dozens of adenoviral vectors expressing genes from various viruses mostly for vaccine application.

Bottom line, viruses do exist and can cause diseases. This depends on a number of factors, the most important being the terrain and the dose of exposure to the viruses. Now are all vaccines work, hell no. Can some work? It really depends on their composition and their route of administration.

My experience is that the majority of vaccines don’t work as advertised and a lot of them do more harm than good. Why? Because of our ignorance of the host/pathogens relationship in which the microbiome plays a crucial role. Also because of our ignorance of how the immune system works to protect us from disease-inducing infections, and cancers. Not to mention the delicate balance that prevent the triggering of auto-immune diseases. In brief, we are so ignorant of the proper functioning of the immune system that our vaccination protocols are, at best sub-optimal, when they are not blatantly deleterious. We are playing apprentice sorcerer and are pushing vaccination as a magic intervention.

The tragedy in all of that is that the regulatory agencies that are supposed to protect the public are not doing their work rigorously enough on solid scientific and technological basis.

Can vaccination be a viable option? In theory yes, but in practice most of the times we simply don’t know enough to make it work as intended.

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